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“冰毒”与其受体TAAR1的分子识别机制研究
课程概要
- Solved the structure of the METH-TAAR1 complex and revealed the molecular basis of therecognition of METH by TAAR1;
- Provided mechanisms of ligand selectivity and polypharmacology between TAAR1 and othermonoamine receptors;
- Clarified the important role of ECL2 and a hydrogen-bonding network in the ligand bindingpockets that may contribute to ligand recognition in TAAR1;
- Elucidated the activation mechanism for TAAR1;
- May provide basis for developing next-generation therapeutics to treat addiction and variousneurological disorders.
