CellTiter-Glo^®细胞活力快速检测系统

CellTiter-Glo^®是基于ATP的裂解型检测方法。萤光素在ATP的参与下，被萤光素酶氧化，产生光。萤光素酶反应的ATP全部来自于活细胞的ATP，因此产生的光强度与活细胞数目成正比。

生物发光法无需激发光，仅需要具有发光检测功能的多功能读板仪，如Promega的GloMax^® Discover system，简单高效，可以检测发光、荧光和吸光。

以“Promega celltiter glo”为关键词在Nature、Science和Cell期刊官网进行搜索，在2015-2023年期间，Celltiter-Glo^®系列产品共被270篇Nature，26 篇Science，195篇Cell 文章使用，共被近7400篇CNS正刊及子刊使用，是当之无愧的高分文献猎手！

铁死亡检测

Li, Y., Ran, Q., Duan, Q. et al. 7-Dehydrocholesterol dictates ferroptosis sensitivity. Nature 626, 411–418 (2024). https://doi.org/10.1038/s41586-023-06983-9

炎性小体检测

Zhang, Z., Shibata, T., Fujimura, A. et al. Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome. Nature 622, 188–194 (2023). https://doi.org/10.1038/s41586-023-06532-4

Pan-KRAS抑制剂研究

Kim, D., Herdeis, L., Rudolph, D. et al. Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature 619, 160–166 (2023).

https://doi.org/10.1038/s41586-023-06123-3

PROTAC研究

Marei, H., Tsai, WT.K., Kee, YS. et al. Antibody targeting of E3 ubiquitin ligases for receptor degradation. Nature 610, 182–189 (2022). 

https://doi.org/10.1038/s41586-022-05235-6

肿瘤微环境研究

Srivatsan R ,S P W ,W A N , et al.Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer.[J].Cell,2021,184(25):6119-6137.e26.

https://doi.org/10.1016/j.cell.2021.11.017

SARS-CoV-2中和试验

Afkhami Sam, et al.Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2.Cell 185.5(2022)

https://doi.org/10.1016/j.cell.2022.02.005

代谢疾病NASH研究

Masaki K ,Takuma I ,Kentaro I , et al.En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH.[J].Cell,2022,185(22):4216-4232.e16.

https://doi.org/10.1016/j.cell.2022.09.031

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